Cell Biology of Tissue Morphogenesis

Caren Norden

The Cell Biology of Tissue Morphogenesis lab aims to untangle the events that lead to the development of organs. In this context, the lab studies the formation of the vertebrate retina from cells to tissue and take the interactions between scales into account. The research group further assesses how mechanics influence tissue formation. Importantly, only when developmental programs occur coordinately from one stage to the next can tissues form correctly in time and space.

 

Thus, the group works on three key steps of retinal formation and investigates their interplay:

1. Elucidating how cells of the optic vesicle rearrange to efficiently form the neuroepithelium and the retinal pigment epithelium that together establish the optic cup.

2. Investigating the proliferation dynamics of neuroepithelial cells leading to optic cup growth until the correct number of cells is generated that poises the system for differentiation. 

3. Resolving how and when neuroepithelial cells enter neurogenesis programs. Furthermore, as neurons are frequently born far away from the position at which they later function, investigating how newborn neurons move to the correct layer within the developing tissue, a process termed neuronal lamination.

To get insights into these fundamental questions, the lab combines methods of cell and developmental biology with advanced quantitative imaging, image analysis tools and, in collaboration, theoretical modeling.