Mouse Facility

The Mouse Facility has full-time expert staff that offers research support services in the laboratory mouse model (mus musculus). The facility has state-of-the-art housing equipments with the capacity to house up to 4,500 cages. The Facility is composed by several independent areas with specific rooms to produce SPF animals, for housing experiments, very specific spaces for germ-free, gnotobiology, and metabolism studies, a quarantine, a ABSL-2 and a ABSL-3 facility. The Facility is open to external researchers.

Location: Main building
Contacts: @: [email protected]

 

Following the Portuguese Law (Decreto Lei nº 113/2013), all research projects that use vertebrate animal models require previous approval by a National Entity, which in Portugal is the Direção Geral de Alimentação e Veterinária (DGAV). These projects must also be approved by the IGC ORBEA (Orgão Responsável pelo Bem-Estar dos Animais). Therefore, the Responsible Investigators of projects that involve the use of vertebrates must enroll in a submission process that starts with a pre-submission step to the Animal Welfare Officer of the IGC.


EQUIPMENT

Animal housing systems SPF (Specific-Pathogen Free)
Germ-free isolators
Gnotobiology housing systems
ISOcage Biosafety Station
Mouse Metabolic Cages System
Controlled-temperature chambers
PyRAT mouse colony software

SERVICES

Space to run research projects. Availability provided upon inquire. Technical feasibility must be assessed (specific equipment availability, biosafety conditions, etc).

Mutant strains can be housed, breed and maintained, following researchers needs and instructions.

Importation and exportation processes of embryos and adult mice are centralized by the Facility.

Quarantine service for all imported animals.

Assisted Reproduction Services for reseting the health status for resident colonies or after importation of new strains (Re-derivation), to revitalize cryopreserved lines (Revitalization), and to rescue poor breeding performance colonies (Strain rescue).

Embryo and sperm cryopreservation services, of diverse genetic backgrounds.

This platform provides rederivation to axenic conditions, production of Germ-Free (GF) C57BL/6 mice, support to researchers with access to organs, tissues and biofluids from GF mice, and technical expertise for running gnotobiology experiments.

Access to a sofisticated metabolic cage-system and temperature-controlled chambers. The Manager of this resource provides close support for the researchers to ensure full optimization of the system (experiment setup; follow-up and data retrieval).

Dedicated animal room to run experiments with BSL-2 agents.

Dedicated animal room to run experiments with BSL-3 agents.

Practical training and research support, and organization of formal LAS courses through the CONGENTO Education and Training group.


PEOPLE


PUBLICATIONS

Check the papers here.


MEDIA


Funding                                    Consortiums

                                    

Updated on 16 march 2023

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