Disease Genetics

Carlos Penha Gonçalves

Disease and organ dysfunction are in many cases controlled by genetic factors. Disease Genetics research group is interested in uncovering how these factors work in specific cell types to drive organ inflammation trajectories and infectious disease outcomes. Under this theme they developed distinct projects working out:

  1. protective roles of trophoblast cells in placental malaria,
  2. the action of brain endothelial cells in propagating inflammation in cerebral malaria and
  3. Kupffer cells responses to liver damage.

To perform this research they have make use of multiple resources including human sample collections, mouse models of disease and optimized cell primary culture systems. This work is leading them to ask how cell-type specific phenotypic adaptation triggered by inflammatory and infectious environments impacts in organ and systemic responses to subsequent challenges.

Researchers expect this research will contribute to bridge the fields of infectious diseases and metabolic disorders elucidating the role of disease adaptation mechanisms in the protection of organic and systemic functions.