Study detects cells that cause leukemia before the disease manifests

Team of researchers led by IGC PI Vera Martins identified the cells that can sustain immune cell differentiation in the thymus and lead to leukaemia initiation, long before the disease manifests. The study published in Cell Reports reveals that these precursor cells ensure that the thymus keeps generating T cells, even in conditions that should compromise this function. But this entails serious consequences: the appearance of abnormal cells, which accumulate errors and trigger leukaemia initiation.

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