INFO-VAC: Oeiras Schools

SARS-CoV-2 AstraZeneca vaccine study to get to know the effectiveness and duration of disease protection

The screening intends to follow up teaching and non-teaching staff, from several schools in Oeiras municipality, after Astrazeneca vaccination and over a period of one year. The data collection in this population and with this vaccine will allow to find out more about the immune system response and the duration of the immunity conferred by the vaccine. A project carried out by the Instituto Gulbenkian de Ciência in partnership with the Group of Health Centers of Western Lisbon and Oeiras and Oeiras Municipality focused on strengthening the epidemiological efforts in recent months.

 

1st phase of the screening

The participants in the screening received the first dose of Astrazeneca vaccine (on March 27 – 28) and were tested in the weekend of April 24- 25.

The 219 participants, teaching and non teaching staff, were integrated in the initiative with the aim of evaluating the response of their immune system.

Throughout the process, periodic blood samples will be collected to understand at all times how each participant responds to the vaccine and what degree of immunity they develop.

One-year follow-up will reveal unknown data.

 

2nd phase of the screening

The second phase of the screening took place during the weekend of June 19 -20 at Pavilhão Desportivo Carlos Queiroz, in Carnaxide. This was the second blood draw and it was carried out at the time of the administration of the second dose. The study is now following up 344 participants in total.

The SARS-CoV-2 vaccine effectiveness has been one of the focus points of research in the IGC, who is following since December 2020 1245 healthcare professionals  and 146 elderly living in nursing homes.

The introduction of vaccines in the population requires close monitoring and surveillance, at the same time the evaluation of the Covid-19 vaccine response has been little studied. Knowing this response, in different populations and in different age groups, is key to adjust vaccination policies or a possible revaccination.

Epidemiological surveillance of vaccine administration is essential to stop the pandemic.

 

3rd phase of the screening

The third phase of the screening took place on 17th July (Saturday) at Fundição de Oeiras. 

 

 

Immunological response in mixed vaccination schemes

According to data from the analysis of antibody levels, of the 1905 people vaccinated and monitored in the study, those who followed a mixed vaccination scheme, with the first dose of Oxford/AstraZeneca and the second dose of Pfizer/BioNTech, generated a greater number of antibodies compared to the two doses of Oxford/AstraZeneca vaccine. The data also revealed that the levels of antibodies, after the two doses of the Pfizer/BioNTech vaccine, were higher than those generated with other vaccination schemes.

Besides following educational professionals from Oeiras Municipality, this longitudinal study also follows health professionals from the Centro Hospitalar Lisboa Ocidental EPE. Learn more about these results here

 


Partners 

       Câmara Municipal de Oeiras              

Updated on 06 january 2022

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