Immune-driven resistance mechanisms can lead to immunopathology and compromise disease tolerance. Regulatory T cells (TREG) restrain immune-driven resistance mechanisms from operating beyond the protective capacity afforded by the transcriptional stress and damage response network.

We found that regulation of iron metabolism impacts on TREG lineage maintenance and function.

Tregtolerance is aimed at elucidating the mechanisms via which this occurs, towards the establishment of disease tolerance.