Lymphocyte Physiology

Jocelyne Demengeot

The research group, led by Jocelyne Demengeot, is concerned with those properties of the immune system that guarantee tissue integrity as well as tolerance to commensals and food antigens while maintaining the ability to mount efficient responses to infectious agents and some tumours. Rooted in this thematic is also the biological puzzle of phenotypic heterogeneity, the challenge of personalised medicine.

The research group approach the cellular and molecular bases of immune regulation through the analysis of various mouse models, notably of spontaneous or induced autoimmune and immuno-pathological inflammation.

Closer to the clinic, they interrogate the biological basis of the most extreme manifestations in autoimmune diseases and of the variable efficacy of immunotherapies.

 

Research Projects

Targets and off targets of recombination activating genes

Targets and off targets of recombination activating genes

The adaptive immune system of the jawed vertebrates emerged about 500 million years ago.

Immune regulation for Immunotherapies

Immune regulation for Immunotherapies

A subset of T cells, expressing the transcription factor Foxp3, dampens immune responses in an antigen specific manner.

 

Publications

 

News

Jocelyne Demengeot, Principal Investigator

PhD in Molecular & Cell Biology, Université d'Aix-Marseille II, France

ORCID

Pubmed

Phone: +351 214 407 908

E-mail: [email protected]