Genome Maintenance and Evolution

Marco Fumasoni

Genome maintenance depends on a number of functional modules that execute and coordinate the complex processes of DNA replication, DNA repair, cell cycle regulation and chromosome segregation.

The Genome Maintenance and Evolution Lab is interested in understanding how cells evolutionary adapt to perturbations in these cellular processes, how the mechanisms of adaptation are influenced by the environment, and what are the physiological and evolutionary consequences of the adaptive changes on organisms.

We take advantage of S.cerevisiae as a model eukaryotic organism and we investigate the molecular mechanisms that allow cells to adapt to perturbations in genome maintenance. We use a multidisciplinary approach that takes advantage of techniques and concepts spanning across biological scales: From molecular and cellular biology to genomics, evolutionary and population genetics.