We are investigating a neurometabolic response regulated at the level of the hypothalamus and acting downstream via the sympathetic nervous system that appears to be essential to establish disease tolerance.

This neurometabolic response regulates:

i) lipolysis in white adipose tissue,

ii) thermogenesis in brown adipose tissue,

iii) glycogenolysis and gluconeogenesis in the liver and

iv) glucagon and insulin release from α and β cells of the pancreas, respectively.

Neurotolerance is aimed at characterizing how this neurometabolic response contributes to the establishment of disease tolerance to viral bacterial or protozoan infections.