Unique regulation of diverse muscle stem and niche cells in development and regeneration

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Several seminars are held weekly at the Instituto Gulbenkian de Ciência, an initiative that aims to bring together all researchers around the topics under discussion.

The sessions, with internal researchers or guests, contribute to stimulate the open and extremely collaborative culture of the IGC.

You can read the abstract of this seminar to learn more about it.


Mouse skeletal muscle stem cells (MuSCs) are functionally heterogeneous, including proliferative capacity and regenerative potential, yet a comprehensive understanding of mechanisms underlying these differences is lacking. Intriguingly, only a subset of muscle groups often succumbs to disease in myopathies. Using a combination of clonal analysis, live imaging and spatiotemporal scRNA-seq, we identified critical regulators of cranial and limb MuSC diversity. Unexpectedly, embryonic and adult extraocular muscle stem cells express distinct ECM and signalling molecules that appear to be regulated by specific transcription factors that constitute a coregulating module throughout development and postnatal growth. These findings provide mechanistic insights into high-performing MuSCs, such as those in the extraocular muscles. They also raise the intriguing possibility that other tissues, like skin and blood that have wide anatomical distributions, could also operate with distinct regulatory properties.


Shahragim Tajbakhsh
Stem Cells & Development, Institut Pasteur, Paris, France


Moises Mallo

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