Biologia Evolutiva
Isabel Gordo
A área de investigação do grupo liderado por Isabel Gordo é a evolução microbiana. Combinam trabalho teórico e empírico de forma a compreender as principais forças modeladoras da variação em populações bacterianas.
Os projetos de investigação atuais e futuros do grupo são:
Membro
Publicações
- Nelson Frazão, Anke Konrad, Massimo Amicone, Elsa Seixas, Daniela Güleresi, Michael Lässig and Isabel Gordo (2022) Two modes of evolution shape bacterial strain diversity in the mammalian gut for thousands of generations. Nature Communications 13
- Hugo C. Barreto, Beatriz Abreu, Isabel Gordo (2022) Fluctuating selection on bacterial iron regulation in the mammalian gut. Current Biology
- Amicone M., Borges, V, Alves, M.J., Isidro, Zé-Zé, J.L., Duarte, S., Vieira, L. , Guiomar, R. , Gomes, J.P., Gordo I. (2022) Mutation rate of SARS-CoV-2 and emergence of mutators during experimental evolution.. Evolution, Medicine, and Public Health
- Balbontín, R., Frazão, N., Gordo, I. (2021) DNA Breaks-Mediated Fitness Cost Reveals RNase HI as a New Target for Selectively Eliminating Antibiotic-Resistant Bacteria. Molecular Biology and Evolution msab093
- Cardoso, LL., Durão, P., Amicone, M., Gordo, I. (2020) Dysbiosis individualizes the fitness effect of antibiotic resistance in the mammalian gut. Nature Ecology & Evolution 1-11
- Frazão, N., Sousa, A., Lässig, M., Gordo, I. (2019) Horizontal gene transfer overrides mutation in Escherichia coli colonizing the mammalian gut. PNAS. 116 (36):17906-17915
- Sousa, A., Frazão, N., Ramiro, R.S., Gordo, I. (2017) Evolution of commensal bacteria in the intestinal tract of mice.. Curr Opin Microbiol. 38:114-121
- Moura de Sousa, J., Balbontín, R., Durão, P. , Gordo, I. (2017) Multidrug-resistant bacteria compensate for the epistasis between resistances. PLoS Biol. 15 (4):e2001741
- Sousa, A., Ramiro, R.S., Barroso-Batista, J., Güleresi, D., Lourenço, M., Gordo, I. (2017) Recurrent reverse evolution maintains polymorphism after strong bottlenecks in commensal gut bacteria.. Mol Biol Evol. msx221
- Durão, P., Güleresi, D., Proença, J., Gordo, I. (2016) Enhanced survival of Rifampicin and Streptomycin double resistant E. coli inside macrophages.. Antimicrob Agents Chemother. 60(7):4324-32
- Barroso-Batista, J., Demengeot, J., Gordo, I. (2015) Adaptive immunity increases the pace and predictability of evolutionary change in commensal gut bacteria. Nat Commun. 6:8945
- Barroso-Batista, J., Sousa, A., Lourenço, M., Bergman, M-L., Sobral, D., Demengeot, J., Xavier, K.B., Gordo, I. (2014) The first steps of adaptation of Escherichia coli to the gut are dominated by soft sweeps.. PLoS Genet. 10(3):e1004182
- Miskinyte, M., Sousa, A., Ramiro, R.S., de Sousa, J.A.M., Kotlinowski, J., Caramalho, I., Magalhães, S., Soares, M.P., Gordo, I. (2013) The genetic basis of Escherichia coli pathoadaptation to macrophages.. PLoS Pathog. 9(12):e1003802
- Sousa, A., Magalhães, A., Gordo, I. (2012) Cost of antibiotic resistance and the geometry of adaptation.. Mol Biol Evol. 29(5):1417-28
- Trindade, S., Sousa, A., Xavier, K.B., Dionisio, F., Ferreira, M.G., Gordo, I. (2009) Positive Epistasis Drives the Acquisition of Multidrug Resistance. PLoS Genet. 5(7):e1000578
- Perfeito, L., Fernandes, L., Mota, C., Gordo, I. (2007) Adaptive Mutations in Bacteria: High Rate and Small Effects.. Science. 317(5839):813-5
