Unique regulation of diverse muscle stem and niche cells in development and regeneration
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Auditório IoniansRua da Quinta Grande, 6
2780-156 Oeiras
Rua da Quinta Grande, 6
2780-156 Oeiras
No IGC decorrem semanalmente diversos seminários, uma iniciativa que pretende reunir todos os investigadores em torno dos temas em debate.
As sessões, com investigadores internos ou convidados, contribuem para estimular a cultura aberta e extremamente colaborativa própria do IGC.
Pode consultar o resumo deste seminário em inglês.
Mouse skeletal muscle stem cells (MuSCs) are functionally heterogeneous, including proliferative capacity and regenerative potential, yet a comprehensive understanding of mechanisms underlying these differences is lacking. Intriguingly, only a subset of muscle groups often succumbs to disease in myopathies. Using a combination of clonal analysis, live imaging and spatiotemporal scRNA-seq, we identified critical regulators of cranial and limb MuSC diversity. Unexpectedly, embryonic and adult extraocular muscle stem cells express distinct ECM and signalling molecules that appear to be regulated by specific transcription factors that constitute a coregulating module throughout development and postnatal growth. These findings provide mechanistic insights into high-performing MuSCs, such as those in the extraocular muscles. They also raise the intriguing possibility that other tissues, like skin and blood that have wide anatomical distributions, could also operate with distinct regulatory properties.
ORADOR
Shahragim Tajbakhsh
Stem Cells & Development, Institut Pasteur, Paris, France