Slider de Eventos
Data
- / Cancelado / Esgotado
Local
Sala virtualNo IGC decorrem semanalmente diversos seminários, uma iniciativa que pretende reunir todos os investigadores em torno dos temas em debate.
As sessões, com investigadores internos ou convidados, contribuem para estimular a cultura aberta e extremamente colaborativa própria do IGC.
Pode consultar o resumo deste seminário em inglês.
Once considered to be a noxious gas, it is now known that hydrogen sulfide (H2S) is generated endogenously in various life forms. In fact, fife evolved and in an H2S-rich environment, eons ago, and with it emerged signal transduction cascades modulated by H2S and sulfhydration. Sulfhydration/persulfidation is a newly discovered posttranslational modification, wherein the -SH groups of reactive cysteine residues are converted to -SSH or persulfide groups. Sulfhydration modulates diverse physiological processes, ranging from response to inflammation to neuroprotection. H2S is generated via the reverse transsulfuration pathway in mammals from the amino acid cysteine and our studies reveal that this pathway is disrupted in aging and in neurodegenerative diseases such as Huntington’s disease, Parkinson’s disease and Alzheimer’s disease. Accordingly, targeting the reverse transsulfuration, may afford therapeutic benefits in neurodegenerative disorders involving imbalanced cysteine and H2S metabolism.
ORADOR
Bindu Paul
Johns Hopkins University, USA