Physical principles of nuclear division

Ivo Telley

The research group is a multidisciplinary team interested in the physical aspects of intracellular organization.

As a model system, they study the earliest stage of Drosophila development, from oogenesis to the mature egg to fertilization and blastoderm cleavages. On one hand, they focus on pronuclear fusion in the fertilized egg and how the syncytial embryo defines the inter-nuclear distance between rapid mitotic divisions. On the other hand, researchers study the physical and biochemical rules determining oocyte polarity.

They use a variety of approaches from chemistry, molecular biology, genetic engineering, micromechanics and optical microscopy.

Their core experimental platform is a cytoplasmic explant assay using single oocytes, mature eggs or early embryos.

 

Research Projects:

  • Physical principles of nuclear migration and position in Drosophila syncytial embryos
  • Cytoskeletal dynamics during inter-nuclear spacing in the Drosophila syncytial embryo
  • Reconstitution of insect fertilization to study intracellular bacteria transmission
  • Reconstitution of cell polarity and axis determination in a cell-free system

 

Publications

 

News

Ivo Telley, Principal Investigator

PhD in Mechanical Engineering, ETH, Zurich, Switzerland

ORCID

Pubmed

Phone: +351 214464606

E-mail: [email protected]