Carlos Penha Gonçalves
Disease and organ dysfunction are in many cases controlled by genetic factors. Disease Genetics research group is interested in uncovering how these factors work in specific cell types to drive organ inflammation trajectories and infectious disease outcomes. Under this theme they developed distinct projects working out:
- protective roles of trophoblast cells in placental malaria,
- the action of brain endothelial cells in propagating inflammation in cerebral malaria and
- Kupffer cells responses to liver damage.
To perform this research they have make use of multiple resources including human sample collections, mouse models of disease and optimized cell primary culture systems. This work is leading them to ask how cell-type specific phenotypic adaptation triggered by inflammatory and infectious environments impacts in organ and systemic responses to subsequent challenges.
Researchers expect this research will contribute to bridge the fields of infectious diseases and metabolic disorders elucidating the role of disease adaptation mechanisms in the protection of organic and systemic functions.
Trophoblasts and placental malaria
Fetal-derived syncytialized trophoblasts are posed at placental barrier in direct contact with maternal blood.
Brain endothelial cells and cerebral malaria
Brain microvessels endothelial cells (BMECs) compose the first layer of the blood brain barrier (BBB).
- Gonçalves, L.A., Rodo, J., Rodrigues-Duarte, L., de Moraes, L.V., Penha-Gonçalves, C. (2017) HGF secreted by activated Kupffer cells induces apoptosis of Plasmodium-infected hepatocytes. Front Immunol. 8 : 90
- de Moraes, L.V., Dechavanne, S., Sousa, P.M., Barateiro, A., Cunha, S.F., Nunes-Silva, S., Lima, F.A., Murillo, O., Marinho, C.R., Gangnard, S., Srivastava, A., Braks, J.A., Janse, C.J., Gamain, B., Franke-Fayard, B., Penha-Gonçalves, C. (2016) Murine Model for Preclinical Studies of Var2CSA-Mediated Pathology Associated with Malaria in Pregnancy. Infect Immun. 84(6) : 1761-74
- Duarte N, Coelho IC, Patarrão RS, Almeida JI, Penha-Gonçalves, C., Macedo MP. (2015) How inflammation impinges on NAFLD: A role for Kupffer cells. Biomed Res Int. 2015 : 984578
- Trovoada, Mde J., Martins, M., Ben Mansour, R., Sambo, M.R., Fernandes, A.B., Gonçalves, L.A., Borja, A., Moya, R., Almeida, P., Costa, J., Marques, I., Macedo, M.P., Coutinho, A., Narum, D.L., Penha-Gonçalves, C. (2014) NOS2 variants reveal a dual genetic control of nitric oxide levels, susceptibility to Plasmodium infection, and cerebral malaria. Infect Immun. 82(3) : 1287-95
- Gonçalves, L.A., Rodrigues-Duarte, L., Rodo, J., de Moraes, L.V., Marques, I., Penha-Gonçalves, C. (2013) TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection. Proc Natl Acad Sci USA. 110(48) : 19531-6
- Ball, E.A., Sambo, M.R., Martins, M., Trovoada, M.J., Benchimol, C., Costa, J., Gonçalves, L.A., Coutinho, A., Penha-Gonçalves, C. (2013) IFNAR1 controls progression to cerebral malaria in children and CD8+ T cell brain pathology in Plasmodium berghei-infected mice. J Immunol. 190(10) : 5118-27
- de Moraes, L.V., Penha-Gonçalves, C. (2013) Placental malaria: from infection to malfunction. Cell Host Microbe. 13(2) : 125-7
- de Moraes, L.V., Tadokoro, C.E., Gómez-Conde, I., Olivieri,, D.N., Penha-Gonçalves, C. (2013) Intravital placenta imaging reveals microcirculatory dynamics impact on sequestration and phagocytosis of Plasmodium-infected erythrocytes. PLoS Pathog. 9(1) : e1003154
- Rodrigues-Duarte, L., de Moraes, L.V., Barboza, R., Marinho, C.R., Franke-Fayard, B., Janse, C.J., Penha-Gonçalves, C. (2012) Distinct placental malaria pathology caused by different Plasmodium berghei lines that fail to induce cerebral malaria in the C57BL/6 mouse. Malar J. 11 : 231
- Côrte-Real, J., Duarte, N., Tavares, L., Penha-Gonçalves, C. (2012) Innate stimulation of B1a cells enhances the autoreactive IgM repertoire in the NOD mouse: implications for type 1 diabetes. Diabetologia 55(6) : 1761-72
- 17 jun 2020
Carlos Penha Gonçalves, Principal Investigator
PhD in Immunology, University of Umea, Sweden
Phone: +351 214 464 634
E-mail: [email protected]