Cell Biology of Tissue Morphogenesis
In the lab, we aim to untangle the events that lead to the development of organs. In this context, we study the formation of the vertebrate retina from cells to tissue and take the interactions between scales into account. We further assess how mechanics influence tissue formation. Importantly, only when developmental programs occur coordinately from one stage to the next can tissues form correctly in time and space.
Thus, we work on three key steps of retinal formation and investigate their interplay:
1. We aim to elucidate how cells of the optic vesicle rearrange to efficiently form the neuroepithelium and the retinal pigment epithelium that together establish the optic cup.
2. We want to investigate the proliferation dynamics of neuroepithelial cells leading to optic cup growth until the correct number of cells is generated that poises the system for differentiation.
3. We resolve how and when neuroepithelial cells enter neurogenesis programs. Furthermore, as neurons are frequently born far away from the position at which they later function, we investigate how newborn neurons move to the correct layer within the developing tissue, a process termed neuronal lamination
To get insights into these fundamental questions, we combine methods of cell and developmental biology with advanced quantitative imaging, image analysis tools and, in collaboration, theoretical modeling.
Caren Norden, Principal Investigator
PhD in Biology, Institute of Biochemistry, ETH Zurich, Switzerland