Obesity

Ana Domingos

The laboratory led by Ana Domingos researches on neuroimmune mechanisms underlying obesity. They discovered the sympathetic neuro-adipose junction, a functional synapse-like connection between white adipocytes and the sympathetic nervous system (Cell 2015).

Researchers also found that this neuro-adipose junction is necessary and sufficient for fat mass reduction via norepinephrine (NE) signaling (Cell 2015, Nature Comm 2017).

They then discovered Sympathetic neuron-Associated Macrophages (SAMs) that directly import and metabolize NE.

Abrogation of SAM function promotes long-term amelioration of obesity independently of food intake (Nature Medicine, 2017).

 

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Updated on 16 january 2020

Ana Domingos, Principal Investigator

PhD in Neurobiology, The Rockefeller University, United States (USA)

ORCID

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Phone: +351 214 464 517

E-mail: [email protected]