Multicellular organisms and microorganisms are continuously interacting. Many of these interactions are mutually beneficial. However, multicellular organisms have to actively thwart invasion by opportunistic or overtly pathogenic microbes.
Host-microorganisms interactions research group is studying the interaction of the model organism Drosophila melanogaster with different microorganisms, in particular intracellular ones. D. melanogaster has been successfully used as a model system to study innate immunity against many pathogens.
Recently it has been shown that there are innate immunity pathways against viruses conserved between insects and mammals. The research group is investigating mechanisms of resistance to viruses in the fruit fly.
Interestingly, they have found that the intracellular bacteria Wolbachia confer resistance to RNA viruses in D. melanogaster. They want to understand the molecular basis of this induced resistance.
Finally, they are interested in the interplay between Drosophila and Wolbachia itself. These endosymbionts are one of the most widespread intracellular bacteria in the world but little is known, at the molecular level, on how the hosts control Wolbachia or Wolbachia manipulate the hosts.
- Faria, V. G., Martins, N. E., Magalhães, S., Paulo, T. F., Nolte, V., Schlötterer, C., Sucena, E., Teixeira, L. (2016) Drosophila Adaptation to Viral Infection through Defensive Symbiont Evolution PLoS Genetics 12(9) : e1006297
- Gutzwiller, F., Carmo, C. R., Miller, D. E., Rice, D. W., Newton, I. L. G., Hawley, R. S., Teixeira, L., Bergman, C.M. (2015) Dynamics of Wolbachia pipientis Gene Expression Across the Drosophila melanogaster Life Cycle G3; Genes|Genomes|Genetics 5(12) : 2843–2856
- Chrostek, E., Teixeira, L. (2015) Mutualism Breakdown by Amplification of Wolbachia Genes PLoS Biology 13(2) : e1002065
- Martins, N. E., Faria, V. G., Nolte, V., Schlotterer, C., Teixeira, L., Magalhães, S., Sucena, É. (2014) Host adaptation to viruses relies on few genes with different cross-resistance properties PNAS 111(16) : 5938–5943
- Chrostek, E., Marialva, M. S. P., Yamada, R., O'Neill, S. L., Teixeira, L. (2014) High Anti-Viral Protection without Immune Upregulation after Interspecies Wolbachia Transfer PLoS ONE 9(6) : e99025
- Martinez, J., Longdon, B., Bauer, S., Chan, Y.-S., Miller, W.J., Bourtziz, K., Teixeira, L., Jiggins, F.M. (2014) Symbionts commonly provide broad spectrum resistance to viruses in insects: a comparative analysis of Wolbachia strains PLoS Pathog 10(9) : e1004369
- Ferreira, A.G, Naylor, H., Esteves, S.E., Pais, I.S., Martins, N.E., Teixeira, L. (2014) The Toll-Dorsal pathway is required for resistance to viral oral infection in DrosophilaPLoS Pathog 10(12) : e1004507
- Martins, N. E., Faria, V. G., Teixeira, L., Magalhães, S., Sucena, É. (2013) Host Adaptation Is Contingent upon the Infection Route Taken by Pathogens PLoS Pathogens 9(9) : e1003601
- Chrostek, E., Marialva, M. S. P., Esteves, S. S., Weinert, L. A., Martinez, J., Jiggins, F. M., Teixeira, L. (2013) Wolbachia Variants Induce Differential Protection to Viruses in Drosophila melanogaster: A Phenotypic and Phylogenomic Analysis PLoS Genetics 9(12) : e1003896
- Teixeira, L., Ferreira, A., Ashburner, M. (2008) The Bacterial Symbiont Wolbachia Induces Resistance to RNA Viral Infections in Drosophila melanogaster Plos Biol 6(12) : e2
- 16 jan 2020
- 25 sep 2019
Luís Teixeira, Principal Investigator
PhD in Biomedical Sciences, Universidade de Lisboa, Portugal
Phone: +351 214 407 938