René Bertholo (Alhandra 1935 - Vila Nova de Cacela, 2005) received his first artistic training at the Escola de Artes Decorativas António Arroio (1947-1951), and then attended the Escola Superior de Belas Artes, Lisbon (1951-1957).
In these years he began to participate in group exhibitions, held his first solo show at Galeria Pórtico (1956) and shared the studio with his friends José Escada, Gonçalo Duarte, and João Vieira (1956). This studio was above the Café Gelo, in Rossio, where artists and writers such as Mário Cesariny, Luiz Pacheco, Herberto Helder gathered.
At Escola Superior de Belas Artes, Lisbon, he met Lourdes Castro, whom he married (1956) and with whom he left, first for Munich and then for Paris (1958). In Paris, they began publishing the magazine KWY, which was the origin of the KWY group (acronym for Ká Wamos Yndo) consisting of Bertholo, Lourdes Castro, Costa Pinheiro, Gonçalo Duarte, José Escada, João Vieira, the German Jan Voss, and the Bulgarian Christo.
The Calouste Gulbenkian Foundation awarded him a grant for his stay in Paris (1959-1960).
He exhibited individually abroad for the first time at Galerie Dragon (Paris, 1963). Throughout the 1960s, he took part in several group exhibitions - in Portugal and abroad - that would link him to the development of Nouvelle Figuration.
From 1966, René Bertholo began to experiment with other forms of artistic creation, building models of small, mechanically driven objects, almost abandoning painting, which he would return to in the 1970s.
He returned permanently to Portugal in 1981. He is represented in the Centro de Arte Moderna collection, and the Serralves Museum dedicated a retrospective exhibition to him (2000).