Obesity
Ana Domingos
The laboratory led by Ana Domingos researches on neuroimmune mechanisms underlying obesity. They discovered the sympathetic neuro-adipose junction, a functional synapse-like connection between white adipocytes and the sympathetic nervous system (Cell 2015).
Researchers also found that this neuro-adipose junction is necessary and sufficient for fat mass reduction via norepinephrine (NE) signaling (Cell 2015, Nature Comm 2017).
They then discovered Sympathetic neuron-Associated Macrophages (SAMs) that directly import and metabolize NE.
Abrogation of SAM function promotes long-term amelioration of obesity independently of food intake (Nature Medicine, 2017).
Publications
- Pereira, M.M.A., Mahú, I., Seixas, E., Martinéz-Sánchez, N., Kubasova, N., Pirzgalska, R.M., Cohen, P., Dietrich, M.O., López, M., Bernardes, G.J.L., Domingos, A.I. (2017) A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages. . Nat Commun. 8:14967
- Pirzgalska, R.M., Seixas, E., Seidman, J.S., Link, V.M., Sánchez, N.M., Mahú, I., Mendes, R., Gres, V., Kubasova, N., Morris, I., Arús, B.A., Larabee, C.M., Vasques, M., Tortosa, F., Sousa, A.L., Anandan, S., Tranfield, E., Hahn, M.K., Iannacone, M., Spann, N.J., Glass, C.K., Domingos, A.I. (2017) Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine. . Nat Med. 14, pp.:[Epub ahead of print]
- Sano, T., Huang, W., Hall, J.A., Yang, Y., Chen, A., Gavzy, S.J., Lee, J., Ziel, J.W., Miraldi, E.R., Domingos, A.I., Bonneau, R., Littman, D.R. (2015) An IL-23R/IL-22 circuit regulates epithelial serum amyloid a to promote local effector Th17 responses.. Cell. 163:381-393
- Huang, W., Thomas, B., Flynn, R.A., Gavzy, S.J., Wu, L., Kim, S.V., Hall, J.A., Miraldi, E.R., Ng, C.P., Rigo, F.W., Meadows, S., Montoya, N.R., Herrera, N.G., Domingos, A.I., Rastinejad, F., Myers, R.M., Fuller-Pace, F.V., Bonneau, R., Chang, H.Y., Acuto, O., Littman, D.R. (2015) DDX5 and its associated lncRNA RMRP modulate Th17 cell effector functions.. Nature. 528:517-522
- Reis, B.S., Lee, K., Fanok, M.H., Mascaraque, C., Amoury, M., Cohn, L.B., Rogoz, A., Danner, O.S., Moraes-Vieira, P.M., Domingos, A.I., Mucida, D. (2015) Leptin receptor signaling in T cells is required for Th17 differentiation. . J Immunol. 194:5253-5260
- Kubasova, N., Burdakov, D., Domingos, A.I. (2015) Sweet and low on leptin: hormonal regulation of sweet taste buds.. Diabetes. 64:3651-3652
- Zeng, W., Pirzgalska, R.M., Pereira, M.M.A., Kubasova, N., Barateiro, A., Seixas, E., Lu, Y., Kozlova, A., Voss, H., Martins, G.G., Friedman, J.M., Domingos, A.I. (2015) Sympathetic neuro-adipose connections mediate leptin-driven lipolysis. . Cell. 163:84-94
- Stanley, S., Domingos, A.I., Kelly, L., Garfield, A., Damanpour, S., Heisler, L., Friedman, J.M. (2013) Profiling of glucose-sensing neurons reveals that GHRH neurons are activated by hypoglycemia. Cell Metabol. 18(4):596-607
- Chaudhury, D.*, Walsh, J.J.,*, Friedman, A.K., Juarez, B., Ku, S.M., Koo, J.W., Ferguson, D., Tsai, H., Pomeranz, L., Christoffel, D.J., Nectow, A. R., Domingos, A.I., Mazie-Robison, M., Mouzon, E., Lobo, M.K., Neve, R.L., Friedman, J.M., Russo, S.J., Deisseroth, K., Nestler, E.J., Han, M.H. *(equal contribution) (2012) Rapid regulation of depression-related behaviors by control of midbrain dopamine neuron. Nature 493 (7433):532-6
- Domingos A.I., Vaynshteyn, J., Voss, H., Ren, X., Gradinaru, V., Zhang, F., Deisseroth, K., de Araujo, I.E., Friedman, J.M. (2011) Sympathetic Neuro-Adipose Connections Mediate Leptin-Driven Lipolysis. Nat Neurosc. 14:1562–1568