Unravelling the developmental control of tissue growth: the fly abdomen

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No IGC decorrem semanalmente diversos seminários, uma iniciativa que pretende reunir todos os investigadores em torno dos temas em debate.

As sessões, com investigadores internos ou convidados, contribuem para estimular a cultura aberta e extremamente colaborativa própria do IGC.

Pode consultar o resumo deste seminário em inglês.

During development, multicellular organisms undergo stereotypical patterns of tissue growth in space and time, but how this is orchestrated remains unclear. Drosophila histoblast nests are small clusters of progenitor epithelial cells that undergo extensive proliferation to give rise to the abdominal epidermis and are amenable to live-imaging. Taking advantage of the recent development of analytical tools that capture cell and tissue deformations, we performed a quantitative analysis of the temporal dynamics of abdomen growth. I will present our latest work on how precisely timed transitions in proliferative behaviour define the developmental growth of our model tissue.



Nicolas Tapon
Crick Institute, London, UK


Caren Norden