Kupffer cells and hepatotoxic damage

Liver resident macrophages (Kupffer cells) play critical roles in the response to liver injury.

Researchers are investigating liver recovery after hepatotoxic damage, which induces profound depletion of Kupffer cells followed by macrophage repopulation.

The findings indicate that hepatotoxic liver damage imposes alterations in the ontogenic composition of the post-recovery liver macrophage populations with Kupffer-like phenotype (e.g. high representation of hematopoietic-derived macrophages).

Researchers want to uncover the role of macrophages in resolution of liver damage by asking whether in the aftermath of an initial hepatotoxic injury macrophage phenotypic adaptation improves hepatic tissue resilience to subsequent challenges.

They expect this research to highlight how phenotypic plasticity of non-parenchymal cell-types (particularly macrophages) protects tissues against prolonged or multiple insults.

Updated on 08 january 2020

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